# November 7, 2026 — Focused HORIZON numerical-report update

[Home](../README.md) · [Latest](../LATEST.md) · [Cardiovascular notes](../topics/07_cardiovascular.md#note-2026-11-07-pelacarsen-horizon-full-results)

**Run kind:** manual focused partial update. **Local date:** November 7, 2026, America/New_York. This is not a completed scheduled worldwide watchlist review. All 33 full-topic successful-check timestamps and baseline-completion flags are preserved.

## Meaningful new evidence

One event, `pelacarsen_horizon_full_results_2026-11-07`: November 7 numerical reporting adds HR 1.02 (95% CI 0.90–1.15), placebo-adjusted 12-month Lp(a) reduction of 77.7%, and adverse-event discontinuation rates of 20.6% versus 7.5% to HORIZON’s already-saved September 4 negative topline. The trial tests monthly subcutaneous pelacarsen 80 mg against placebo in secondary prevention. [Full finding and limitations](../topics/07_cardiovascular.md#note-2026-11-07-pelacarsen-horizon-full-results).

## Evidence and access record

- [Investigator-institution account](https://consultqd.clevelandclinic.org/lipoproteina-reduction-with-pelacarsen-has-no-impact-on-cardiac-events), dated November 7: numerical efficacy, follow-up and safety retrieved through the indexed original article; direct page fetch was blocked.
- [Official AHA report](https://newsroom.heart.org/news/lp-a-horizon-trial-lp-a-fell-by-78-but-cardiovascular-outcomes-unexpectedly-neutral), dated November 7: trial design, presentation, selected harms and contextual limitations retrieved from the indexed original account.
- [Registry](https://clinicaltrials.gov/study/NCT04023552), last updated August 28: completed Phase 3 protocol, dose and dates; no results section. That older update date is not rebranded as new news.
- [NEJM paper](https://www.nejm.org/doi/full/10.1056/NEJMoa2610159), November 7: exact title, DOI and publication date confirmed through [publisher metadata](https://api.crossref.org/works/10.1056/NEJMoa2610159); direct full text/abstract/PDF inaccessible. No numerical assertion relies on an unread manuscript table.

**Unresolved:** Investigator enrollment/analysis counts differ from AHA and registry enrollment. Exact efficacy-arm and safety denominators, crude-versus-time-to-event basis of reported event percentages, precise safety windows and full manuscript tables remain unverified. No p-value, NNT/NNH, absolute-risk calculation or fabricated survival/biomarker curve is added. Unequal mean drug exposure remains visible. This result does not resolve other Lp(a) agents or primary prevention.

**ZEUS:** Its negative July topline is preserved. The separately scheduled November 7 fuller report remains unappraised in this focused task; it is not treated as a new result or as proof that the presentation has not occurred.

**Informal coverage:** No new source-grounded rumor is selected. A comprehensive new Reddit, podcast/talk and AHA-Q&A sweep was not performed; unresolved existing claims retain their prior history.

## Coverage of active topics

| Topic | Coverage in this run |
| --- | --- |
| [Whole-body MRI](../topics/01_whole_body_mri.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Galleri and organ-specific cancer screening](../topics/02_galleri.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [GLP-1 and related metabolic therapies](../topics/03_glp1.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Muscle building and preservation](../topics/04_muscle.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Longevity and healthspan trials](../topics/05_longevity.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Localized fat removal and cellulite](../topics/06_localized_fat.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Broad cardiovascular prevention, lipids and screening](../topics/07_cardiovascular.md) | Focused HORIZON numerical-report appraisal only; other cardiovascular programs and ZEUS not reappraised. |
| [Alzheimer's screening and therapies](../topics/08_alzheimers.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Psilocybin and related therapies](../topics/09_psychedelics.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Mental-health treatments, SSRIs and newer antidepressants](../topics/10_ssri_antidepressants.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Bone health, joint preservation and cartilage repair](../topics/11_joint_preservation.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Liver health and noninvasive assessment](../topics/13_liver.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Cancer treatment, vaccines and recurrence prevention](../topics/14_cancer_vaccines.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Autoimmune disease and immune reset](../topics/15_autoimmune.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Non-opioid pain treatments](../topics/16_pain.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Kidney preservation and earlier detection](../topics/17_kidney.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Hearing and vision preservation/restoration](../topics/18_hearing_vision.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Hair loss, restoration and graying](../topics/19_hair_loss.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Skin aging, laxity and regeneration](../topics/20_skin_aging.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Scar prevention, treatment and stretch marks](../topics/21_scars.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Facial volume restoration and contour](../topics/22_facial_volume.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Pigmentation and uneven skin tone](../topics/23_pigmentation.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Acne and rosacea](../topics/24_acne_rosacea.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Dental alignment, regeneration and repair](../topics/25_dental.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Allergy and airway disease](../topics/26_allergy_airway.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Infectious-disease prevention and treatment](../topics/27_infectious_disease.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Genetic screening and risk prediction](../topics/28_genetic_screening.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Insomnia](../topics/29_sleep_insomnia.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Obstructive sleep apnea](../topics/30_sleep_apnea.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Narcolepsy & excessive sleepiness](../topics/31_sleep_hypersomnolence.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Circadian rhythm disorders](../topics/32_sleep_circadian.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| [Restless legs syndrome](../topics/33_sleep_restless_legs.md) | Not rechecked in this focused manual update; prior gaps and verification dates retained. |

The retained sleep history hub is unchanged and is not a duplicate monitoring assignment. Catalog IDs, paths and browse groups are unchanged. Untouched topics are not labeled “no news.”

## Notebook and publication maintenance

The cardiovascular current summary and precise finding anchor, README preview, latest feed, landscape, milestone calendar and this log/index are updated together. The new report resolves the HORIZON numerical-report window; the calendar keeps ZEUS awaiting appraisal and the remaining HORIZON table/development questions undated. Original notes, source dates, September topline and older run records are preserved.

State is saved only after notebook readback. One stable event is appended; only cardiovascular focused-check metadata advances. Full-success timestamps, baseline flags, all previous events and other topic state are unchanged. Website publication is pending; the preceding successful deployment receipt is retained until the validated new edition is published and verified.