November 7, 2026 — Focused HORIZON numerical-report update
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Run kind: manual focused partial update. Local date: November 7, 2026, America/New_York. This is not a completed scheduled worldwide watchlist review. All 33 full-topic successful-check timestamps and baseline-completion flags are preserved.
Meaningful new evidence
One event, pelacarsen_horizon_full_results_2026-11-07: November 7 numerical reporting adds HR 1.02 (95% CI 0.90–1.15), placebo-adjusted 12-month Lp(a) reduction of 77.7%, and adverse-event discontinuation rates of 20.6% versus 7.5% to HORIZON’s already-saved September 4 negative topline. The trial tests monthly subcutaneous pelacarsen 80 mg against placebo in secondary prevention. Full finding and limitations.
Evidence and access record
- Investigator-institution account, dated November 7: numerical efficacy, follow-up and safety retrieved through the indexed original article; direct page fetch was blocked.
- Official AHA report, dated November 7: trial design, presentation, selected harms and contextual limitations retrieved from the indexed original account.
- Registry, last updated August 28: completed Phase 3 protocol, dose and dates; no results section. That older update date is not rebranded as new news.
- NEJM paper, November 7: exact title, DOI and publication date confirmed through publisher metadata; direct full text/abstract/PDF inaccessible. No numerical assertion relies on an unread manuscript table.
Unresolved: Investigator enrollment/analysis counts differ from AHA and registry enrollment. Exact efficacy-arm and safety denominators, crude-versus-time-to-event basis of reported event percentages, precise safety windows and full manuscript tables remain unverified. No p-value, NNT/NNH, absolute-risk calculation or fabricated survival/biomarker curve is added. Unequal mean drug exposure remains visible. This result does not resolve other Lp(a) agents or primary prevention.
ZEUS: Its negative July topline is preserved. The separately scheduled November 7 fuller report remains unappraised in this focused task; it is not treated as a new result or as proof that the presentation has not occurred.
Informal coverage: No new source-grounded rumor is selected. A comprehensive new Reddit, podcast/talk and AHA-Q&A sweep was not performed; unresolved existing claims retain their prior history.
Coverage of active topics
| Topic | Coverage in this run |
|---|---|
| Whole-body MRI | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Galleri and organ-specific cancer screening | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| GLP-1 and related metabolic therapies | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Muscle building and preservation | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Longevity and healthspan trials | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Localized fat removal and cellulite | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Broad cardiovascular prevention, lipids and screening | Focused HORIZON numerical-report appraisal only; other cardiovascular programs and ZEUS not reappraised. |
| Alzheimer's screening and therapies | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Psilocybin and related therapies | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Mental-health treatments, SSRIs and newer antidepressants | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Bone health, joint preservation and cartilage repair | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Liver health and noninvasive assessment | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Cancer treatment, vaccines and recurrence prevention | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Autoimmune disease and immune reset | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Non-opioid pain treatments | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Kidney preservation and earlier detection | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Hearing and vision preservation/restoration | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Hair loss, restoration and graying | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Skin aging, laxity and regeneration | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Scar prevention, treatment and stretch marks | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Facial volume restoration and contour | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Pigmentation and uneven skin tone | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Acne and rosacea | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Dental alignment, regeneration and repair | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Allergy and airway disease | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Infectious-disease prevention and treatment | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Genetic screening and risk prediction | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Insomnia | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Obstructive sleep apnea | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Narcolepsy & excessive sleepiness | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Circadian rhythm disorders | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
| Restless legs syndrome | Not rechecked in this focused manual update; prior gaps and verification dates retained. |
The retained sleep history hub is unchanged and is not a duplicate monitoring assignment. Catalog IDs, paths and browse groups are unchanged. Untouched topics are not labeled “no news.”
Notebook and publication maintenance
The cardiovascular current summary and precise finding anchor, README preview, latest feed, landscape, milestone calendar and this log/index are updated together. The new report resolves the HORIZON numerical-report window; the calendar keeps ZEUS awaiting appraisal and the remaining HORIZON table/development questions undated. Original notes, source dates, September topline and older run records are preserved.
State is saved only after notebook readback. One stable event is appended; only cardiovascular focused-check metadata advances. Full-success timestamps, baseline flags, all previous events and other topic state are unchanged. Website publication is pending; the preceding successful deployment receipt is retained until the validated new edition is published and verified.